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What Formula Is Best for Constipation?

📅 Updated February 2026⏱️ 5 min readNEW

TL;DR

If your baby is constipated, switch to a palm oil-free formula with partially hydrolyzed proteins. Palm oil reacts with calcium in a baby's gut to form hard "soaps" that cause severe constipation. Skip heavily marketed "regulating" formulas that still contain palm oil, and opt for cleaner European-style or goat milk alternatives.

🔑 Key Findings

1

Palm olein oil is the leading dietary cause of hard stools in formula-fed infants.

2

Enfamil Reguline, marketed specifically for constipation, contains palm olein oil.

3

A 60:40 whey-to-casein ratio digests significantly faster than casein-heavy formulas.

4

Severe, sudden constipation is the first symptom of infant botulism—a critical warning following the massive late-2025 ByHeart formula recall.

The Short Answer

If your baby is struggling to poop, switch to a palm oil-free formula with partially hydrolyzed proteins.

Palm oil (often listed as palm olein) reacts with calcium in a baby's gut to form hard, cement-like "soaps" that cause severe constipation. Bobbie Gentle, Kendamil Comfort, and HiPP Comfort are top choices because they skip palm oil entirely and break down the milk proteins for easier digestion.

Why This Matters

Formula-fed babies are significantly more prone to constipation than breastfed babies. The reason usually comes down to the fat blend.

Breast milk is rich in palmitic acid, so mainstream formula manufacturers use palm oil to mimic it. The problem? Baby guts don't process palm oil the same way. Instead of absorbing it smoothly, the palm oil binds with calcium in the intestines, creating hard stools that are painful to pass. Palm Oil Formula Bad

Switching to a formula with a different fat source—like whole milk fat or coconut oil—is often all it takes to get things moving. You don't necessarily need a "specialty" constipation formula. In fact, some heavily marketed constipation formulas actually contain the very ingredients causing the problem.

⚠️ Urgent ByHeart Warning

If you recently fed your baby ByHeart formula and they developed severe constipation, call your pediatrician immediately.

In November 2025, ByHeart recalled its formulas nationwide due to infant botulism contamination. The very first symptom of infant botulism is typically severe constipation, followed by muscle weakness, drooping eyelids, and poor feeding. Baby Formula Recalls

What's Actually In "Constipation" Formula

Let's look at Enfamil Reguline, the #1 pediatrician-recommended formula specifically designed to promote soft stools.

  • Partially Hydrolyzed ProteinsGood. Broken-down proteins are easier for a newborn's immature gut to digest. Easiest Digest Formula
  • Prebiotics (Polydextrose & GOS)Good. These feed healthy gut bacteria and draw water into the bowel.
  • Palm Olein OilA massive red flag. Palm Oil Baby Formula Enfamil adds prebiotics to soften the stool, but keeps the cheap palm olein oil that hardens it in the first place.

What to Look For

Green Flags:

  • Palm Oil-Free — Look for coconut oil, sunflower oil, or whole milk fats instead.
  • Partially Hydrolyzed Proteins — The milk proteins are pre-digested, making them gentler on the digestive tract.
  • Whey-Dominant Ratio — Whey is liquid-based and digests quickly; casein forms curds and digests slowly. Look for a 60:40 whey-to-casein ratio.
  • Goat Milk — Goat milk proteins naturally form softer, smaller curds in the stomach than cow's milk, making it a great natural alternative. Goat Vs Cow Milk Formula

Red Flags:

  • Palm Oil or Palm Olein — The number one dietary culprit for formula-induced constipation.
  • Intact Casein Proteins — Harder for immature digestive systems to break down, leading to slower digestion.
  • Corn Syrup Solids — Often used as a cheap carbohydrate replacement in "gentle" formulas. Is Corn Syrup Formula Bad

The Best Options

You don't need a formula with "Constipation" on the label. You just need a formula with clean fats and gentle proteins.

BrandProductVerdictWhy
KendamilComfortUses whole milk fats instead of palm oil, plus partially hydrolyzed proteins.
BobbieGentle100% partially hydrolyzed whey protein with zero palm oil.
HiPPComfortExtensively hydrolyzed whey with a special fat blend designed for gut health.
NannycareGoat MilkNaturally forms softer curds in the stomach without aggressive processing.
EnfamilReguline🚫Contains palm olein oil, defeating the purpose of a constipation formula.
ByHeartWhole Nutrition🚫Currently under a massive FDA recall for botulism contamination.

The Bottom Line

1. Check the ingredient list for palm oil. If it's there, switch to a palm-free brand immediately.

2. Try a partially hydrolyzed formula. Broken-down proteins move through the digestive tract faster and with less effort.

3. Consider goat milk. It naturally digests faster and forms softer curds than standard cow's milk. Is Bobbie Good

FAQ

Does the iron in formula cause constipation?

Usually, no. While iron supplements in adults cause constipation, the regulated amount of iron in baby formula is rarely the culprit. Palm oil and heavy casein proteins are far more likely to cause hard stools. Do not switch to a low-iron formula without consulting your pediatrician.

Can I add extra water to the formula to help constipation?

Never do this. Diluting formula is incredibly dangerous and can lead to water intoxication and fatal electrolyte imbalances. Always mix formula exactly according to the package directions. Tap Water Formula

How long does it take for a new formula to fix constipation?

Give it one to two weeks. It takes time for your baby's gut microbiome to adjust to a new fat and protein blend. Unless your baby is showing signs of an allergic reaction (or symptoms of botulism), be patient before switching again.


References (10)
  1. 1. womenshealthmag.com
  2. 2. hellosubscription.com
  3. 3. bumblebabychicago.com
  4. 4. hibobbie.com
  5. 5. organicsbestshop.com
  6. 6. childrensnational.org
  7. 7. fda.gov
  8. 8. alibaba.com
  9. 9. oli6.com
  10. 10. aap.org

🛒 Product Recommendations

Kendamil Comfort

Kendamil

Uses whole milk fats instead of palm oil and partially hydrolyzed proteins.

Recommended
Bobbie Gentle

Bobbie

100% partially hydrolyzed whey protein with zero palm oil.

Recommended
HiPP Comfort

HiPP

Features extensively hydrolyzed whey proteins and a special fat blend designed for gut health.

Recommended
🚫
Enfamil Reguline

Enfamil

Adds prebiotics to soften stool but ruins it by including palm olein oil.

Avoid
🚫
ByHeart Whole Nutrition

ByHeart

Currently under a massive FDA recall due to infant botulism contamination.

Avoid

Kendamil Goat Infant Formula

Kendamil

This formula combines the natural digestibility of A2 goat milk proteins with a fat blend that is completely free of palm oil. Unlike many goat formulas that still rely on palm olein, Kendamil uses whole goat milk fats to create softer curds in the stomach.

Recommended
Similac Pro-Total Comfort

Similac

Specifically designed for sensitive tummies, this formula uses 100% partially hydrolyzed whey protein that is easy to digest. Crucially, it uses a palm oil-free fat blend (safflower, soy, and coconut oils) to prevent calcium soap formation.

Recommended

Bubs Supreme A2 Beta-Casein Formula

Bubs Australia

While their goat formula contains palm oil, Bubs' premium cow milk formula is entirely palm oil-free. It features A2 beta-casein protein, which studies suggest causes less digestive discomfort and inflammation than standard A1 cow milk proteins.

Recommended
Kabrita Goat Milk Toddler Formula

Kabrita

Kabrita is a rare exception to the 'no palm oil' rule because it uses a specialized fat blend with beta-palmitate (OPO). This structure mimics the fat in breast milk and has been clinically shown to prevent the formation of calcium soaps, unlike standard palm oil.

Recommended

Kirkland Signature ProCare

Costco / Perrigo

An excellent budget-friendly option that is completely free of palm olein oil. It matches the nutritional profile of premium brands like Similac Pro-Advance, including 2'-FL HMO prebiotics for gut health, without the constipation-causing fats.

Recommended
Baby's Only Organic Gentle

Nature's One

This formula pairs organic A2 milk proteins with a 100% palm oil-free fat blend. It is also one of the few formulas that avoids corn syrup solids, using organic lactose as the primary carbohydrate source to support healthy digestion.

Recommended
Similac 360 Total Care Sensitive

Similac

Designed for fussiness and gas, this formula supports gut health with a blend of 5 HMO prebiotics. It explicitly excludes palm olein oil, making it a safer choice for prone-to-constipation infants compared to other 'sensitive' brands.

Recommended
Similac Pure Bliss Irish Farms

Similac

Sourced from grass-fed cows in Ireland, this formula offers a clean ingredient profile with no artificial growth hormones. It strictly avoids palm olein oil, relying instead on high-oleic sunflower and coconut oils for better calcium absorption.

Recommended
👌

Else Nutrition Plant-Based Complete Nutrition

Else Nutrition

For toddlers with severe dairy intolerance contributing to constipation, this plant-based option uses almond and buckwheat instead of soy or cow milk. It is Clean Label Project certified and free from palm oil and gums.

Acceptable
Bobbie Organic Infant Formula

Bobbie

Modeled after European standards, Bobbie uses a simple recipe with organic lactose and a fat blend of sunflower, soy, and coconut oils. Its total exclusion of palm oil helps ensure softer stool consistency for formula-fed babies.

Recommended
👌

Similac Soy Isomil

Similac

If a doctor recommends a soy-based diet, this is a superior choice over competitors because it is palm oil-free. Soy formulas can sometimes be constipating, so avoiding palm olein here is critical for keeping stools soft.

Acceptable
🚫

Enfamil NeuroPro Gentlease

Enfamil

Despite being marketed for 'gentle' digestion, the #1 ingredient in its fat blend is palm olein oil. This creates the exact calcium soaps that cause harder stools, counteracting the benefits of its hydrolyzed proteins.

Avoid
🚫

Gerber Good Start SoothePro

Gerber

Marketed to soothe colic and fussiness, this formula unfortunately relies on a fat blend containing palm olein. While the probiotic L. reuteri is beneficial, the presence of palm oil remains a major risk factor for constipation.

Avoid
🚫

Earth's Best Organic Sensitivity

Earth's Best

Being organic doesn't make it constipation-proof; this formula lists 'organic palm oil or palm olein' as a primary fat source. Additionally, it uses glucose syrup solids instead of lactose, which can affect gut motility in some infants.

Avoid
🚫

Up & Up Gentle Premium

Target

As a generic version of Enfamil Gentlease, this store brand replicates the same formulation issues. It contains palm olein oil as a primary fat, meaning it will cause the same hard stool issues as the name brand it mimics.

Avoid
🚫
Parent's Choice Gentle

Walmart

Another generic copy of Enfamil Gentlease that mimics the fat blend including palm olein. Parents seeking a budget 'gentle' formula should switch to Kirkland ProCare or a Similac generic that is palm-free.

Avoid
🚫

Enfamil A.R.

Enfamil

Designed to reduce spit-up with added rice starch, the thickener combined with palm olein oil creates a 'double whammy' for constipation. The rice constipates by nature, and the palm oil adds calcium soaps to the mix.

Avoid
⚠️

Happy Baby Organic Sensitive

Happy Baby

While it includes prebiotics for gut health, the ingredient list reveals 'organic palm olein or palm oil.' For a baby already struggling with hard stools, the organic label does not negate the chemical reaction between palm fats and calcium.

Use Caution
⚠️

Bubs Goat Milk Infant Formula (US Version)

Bubs Australia

Unlike Bubs' cow milk formulas which are palm-free, their US goat milk formula includes 'sustainable palm olein' in the vegetable oil blend. Parents switching to goat milk for digestion should check the label carefully.

Use Caution
⚠️

Pepticate

Nutricia

This is an extensively hydrolyzed formula for cow's milk allergy (CMA), but it surprisingly contains palm oil. If your baby needs a hypoallergenic formula but is getting constipated on this one, consult your GI specialist about alternatives.

Use Caution
⚠️

Holle Goat Milk Formula (Stage 1)

Holle

A popular European import, but it traditionally uses a fat blend that includes palm oil. While the quality is high and organic, the palm fat content can still lead to firmer stools compared to palm-free goat options like Kendamil.

Use Caution
🚫

Enfamil ProSobee Soy

Enfamil

Soy formulas are naturally more binding than milk-based ones. Enfamil exacerbates this by using palm olein in their soy formula, whereas Similac's soy alternative is palm-free.

Avoid

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